Characterization of Esophageal Cancers
The perception of taste allows one to assess whether ingested substances are nutritious or potentially hazardous, but this sense is frequently impaired in case of pathology or following chemotherapy. We recently identified taste buds clustered in the mouse esophagus and compared mechanisms regulating development of taste receptor cells in the tongue and esophagus at single cell resolution.
This study features on the cover of Science Advances
To learn more about the relationship between an embryonic transcriptomic program and columnar metaplasia in the esophagus, see our latest publication in Cell Stem Cell.
This work was supported by:
In vitro models
Our recent study published in Biology suggests that response to therapy might be enhanced by optimizing the time of treatment (endogenous clock time). The full article can be found here.