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Characterization of Esophageal Cancers

& Metaplasia


Vercauteren Drubbel, A. & Beck, B. (2023, Mar). Single cell transcriptomics uncovers the differentiation of a subset of murine esophageal progenitors into taste buds in vivo. 10;9(10):eadd9135. Sci. Adv.


Bregni, G., & Beck, B. (2022, Mar). Toward Targeted Therapies in Oesophageal Cancers: An Overview. Cancers 2022, 14(6), 1522.

Vercauteren Drubbel, A. & Beck, B. (2021, Oct). Dedifferentiation of esophageal progenitors in metaplasia and cancer. Molecular and Cellular Oncology

Vercauteren Drubbel, A., Pirard, S., Kin, S., Dassy, B., Lefort, A., Libert, F., Nomura, S., Beck, B. (2021, Apr). Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia. Cell Stem Cell S1934-5909(21)00152-1.

Redondo, J.A., Bibes, R., Vercauteren Drubbel, A., Dassy, B., Bisteau, X., Maury, E., Beck, B. (2021, Mar). PER2 Circadian Oscillation Sensitizes Esophageal Cancer Cells to Chemotherapy. Biology 10, 266.

Augereau, A., Mariotti, M., Pousse, M., Filipponi, D., Libert, F., Beck, B., Gorbunova, V., Gilson, E., Gladyshev, V.N. (2021, Feb). Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen. Sci. Adv. 7, eabe0174.

Ramos, AR., Ghosh, S., Suhel, T., Chevalier, C., Obeng, EO., Fafilek, B., Krejci, P., Beck, B., Erneux, C. (2019, Oct). Phosphoinositide 5-phosphatases SKIP and SHIP2 in ruffles, the endoplasmic reticulum and the nucleus: An update. Adv Biol Regul. doi: 10.1016/j.jbior.2019.100660.

Cox, B., Laporte, E., Vennekens, A., Kobayashi, H., Nys, C., Van Zundert, I., Uji-I, H., Vercauteren Drubbel, A., Beck, B., Roose, H., Boretto, M., Vankelecom, H. (2019, Feb). Organoids from pituitary as a novel research model toward pituitary stem cell exploration. J Endocrinol. doi: 10.1530/JOE-18-0462.

Latil, M., Nassar, D., Beck, B., Boumahdi, S., Wang, L. L., Brisebarre, A., Dubois, C., Nkusi, E., Lenglez, S., Checinska, A., Vercauteren Drubbel, A., Devos, M. M., Declercq, W., Yi, R. R., & Blanpain, C. (2016, novembre). Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition. Cell stem cell. doi:10.1016/j.stem.2016.10.018 

Adriaens, C. C., Standaert, L. L., Barra, J. J., Latil, M., Verfaillie, A. A., Kalev, P. P., Boeckx, B. B., Wijnhoven, P. W. G. P., Radaelli, E., Vermi, W., Leucci, E. E., Lapouge, G., Beck, B., van den Oord, J., Nakagawa, S. S., Hirose, T. T., Sablina, A. A., Lambrechts, D., Aerts, S., Blanpain, C., & Marine, J.-C. (2016, août). P53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nature medicine, 22(8), 861-868. doi:10.1038/nm.4135


Bidaux, G., Borowiec, A.-S., Gordienko, D., Beck, B., Shapovalov, G. G., Lemonnier, L., Flourakis, M., Vandenberghe, M. M., Slomianny, C., Dewailly, E. E., Delcourt, P., Desruelles, E. E., Ritaine, A. A., Polakowska, R., Lesage, J. J., Chami, M. M., Skryma,R., & Prevarskaya, N. (2015, juin). Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner. Proceedings of the National Academy of Sciences of the United States of America, 112(26), E3345-E3354. doi:10.1073/pnas.1423357112


Beck, B., Lapouge, G., Rorive, S., Drogat, B., Desaedelaere, K., Delafaille, S., Dubois, C., Salmon, I., Willekens, K., Marine, J.-C., & Blanpain, C. (2015). Different Levels of Twist1 Regulate Skin Tumor Initiation, Stemness, and Progression. Cell Stem Cell, 16(1), 67-79. doi:10.1016/j.stem.2014.12.002














Raphaël, M. M., Lehen'kyi, V., Vandenberghe, M. M., Beck, B., Khalimonchyk, S. S., Vanden Abeele, F., Farsetti, L. L., Germain, E. E., Bokhobza, A. A., Skryma, R., Prevarskaya, N., Mihalache, A. A., Gosset, P. P., Romanin, C. C., & Clezardin, P. (2014, septembre). TRPV6 calcium channel translocates to the plasma membranevia Orai1-mediated mechanism and controls cancer cell survival. Proceedings of the National Academy of Sciences of the United States of America, 111(37), E3870-E3879. doi:10.1073/pnas.1413409111


Boumahdi, S., Driessens, G., Lapouge, G., Rorive, S., Nassar, D., Le Mercier, M., Delatte, B., Caauwe, A., Lenglez, S., Nkusi, E., Brohée, S., Salmon, I., Dubois, C., Del Marmol,V., Fuks, F., Beck, B., & Blanpain, C. (2014, juin). SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma. Nature (London). doi:10.1038/ nature13305

Beck, B., & Blanpain, C. (2013, octobre). Unravelling cancer stem cell potential. Nature reviews. Cancer, 13(10), 727-738. doi:10.1038/nrc3597  


Lapouge, G., Beck, B., Nassar, D., Dubois, C., Dekoninck, S., & Blanpain, C. (2012, novembre). Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness. EMBO journal, 31(24), 4563-4575. doi:10.1038/ emboj.2012.312


Driessens, G., Beck, B., Caauwe, A., Simons, B. D., & Blanpain, C. (2012, août). Defining the mode of tumour growth by clonal analysis. Nature (London). doi:10.1038/nature11344

Beck, B., & Blanpain, C. (2012, mai). Mechanisms regulating epidermal stem cells. EMBO journal, 31(9), 2067-2075. doi:10.1038/emboj.2012.67


Bidaux, G., Beck, B., Zholos, A., Gordienko, D., Lemonnier, L., Flourakis, M., Roudbaraki, M., Borowiec, A.-S., Fernandez, J. P., Delcourt, P., Lepage, G., Shuba, Y., Skryma, R.,& Prevarskaya, N. (2012, janvier). Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms. The Journal of biological chemistry, 287(5), 2948-2962. doi:10.1074/jbc.M111.270256


Van Keymeulen, A., Rocha, A. S., Ousset, M., Beck, B., Bouvencourt, G., Rock, J., Sharma, N., Dekoninck, S., & Blanpain, C. (2011, octobre). Distinct stem cells contribute to mammary gland development and maintenance. Nature (London), 478. doi:10.1038/ nature10573


Beck, B., Driessens, G., Goossens, S., Kass, Y. K., Kuchnio, A., Caauwe, A., Sotiropoulou, P., Loges, S., Lapouge, G., Candi, A., Mascré, G., Drogat, B., Dekoninck, S., Haigh, J. J., Carmeliet, P., & Blanpain, C. (2011, octobre). A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature (London), 478(7369), 399-403. doi:10.1038/nature10525


Bondue, A., Tannler, S., Chiapparo, G., Chabab, S., Ramialison, M., Paulissen, C., Beck, B., Harvey, R., & Blanpain, C. (2011, mars). Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation. The Journal of cell biology, 192(5), 751-765. doi:10.1083/jcb.201007063


Bonnefont, J., Laforge, T., Plastre, O., Beck, B., Sorce, S., Dehay, C., & Krause, K.-H. (2011, février). Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation. Cell death and differentiation, 18(2), 293-303. doi:10.1038/ cdd.2010.102


Bavencoffe, A., Gkika, D., Kondratskyi, A., Beck, B., Borowiec, A.-S., Bidaux, G., Busserolles, J., Eschalier, A., Shuba, Y., Skryma, R., & Prevarskaya, N. (2010, mars). The transient receptor potential channel TRPM8 is inhibited via the alpha 2A adrenoreceptor signaling pathway. The Journal of biological chemistry, 285(13), 9410-9419. doi:10.1074/ jbc.M109.069377 -


Kass, Y. K., Van Keymeulen, A., Lapouge, G., Beck, B., Michaux, C., Achouri, Y., Sotiropoulou, P., & Blanpain, C. (2010, février). Identification of the cell lineage at the origin of basal cell carcinoma. Nature cell biology. doi:10.1038/ncb2031


Flourakis, M., Lehen'kyi, V., Beck, B., Raphaël, M., Vandenberghe, M., Abeele, F.V., Roudbaraki, M., Lepage, G., Mauroy, B., Romanin, C., Shuba, Y., Skryma, R.,& Prevarskaya, N. (2010). Orai1 contributes to the establishment of an apoptosis- resistant phenotype in prostate cancer cells. Cell death and disease, 1, 75. doi:10.1038/ cddis.2010.52


Beck, B., Lehen'kyi, V., Roudbaraki, M., Flourakis, M., Charveron, M., Bordat, P., Polakowska, R., Prevarskaya, N., & Skryma, R. (2008, mai). TRPC channels determine human keratinocyte differentiation: new insight into basal cell carcinoma. Cell calcium, 43(5), 492-505. doi:10.1016/j.ceca.2007.08.005


Lehen'kyi, V., Beck, B., Polakowska, R., Charveron, M., Bordat, P., Skryma, R., & Prevarskaya, N. (2007, août). TRPV6 is a Ca2+ entry channel essential for Ca2+-induced differentiation of human keratinocytes. The Journal of biological chemistry, 282(31), 22582-22591. doi:10.1074/jbc.M611398200


Bidaux, G., Flourakis, M., Thebault, S., Zholos, A., Beck, B., Gkika, D., Roudbaraki, M., Bonnal, J.-L., Mauroy, B., Shuba, Y., Skryma, R., & Prevarskaya, N. (2007, juin). Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function. The Journal of clinical investigation, 117(6), 1647-1657. doi:10.1172/JCI30168


Beck, B., Bidaux, G., Bavencoffe, A., Lemonnier, L., Thebault, S., Shuba, Y., Barrit, G., Skryma, R., & Prevarskaya, N. (2007, mars). Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell calcium, 41(3), 285-294. doi:10.1016/ j.ceca.2006.07.002


Vanden Abeele, F., Zholos, A., Bidaux, G., Shuba, Y., Thebault, S., Beck, B., Flourakis, M., Panchin, Y., Skryma, R., & Prevarskaya, N. (2006, décembre). Ca2+-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids. The Journal of biological chemistry, 281(52), 40174-40182. doi:10.1074/jbc.M605779200


Beck, B., Zholos, A., Sydorenko, V., Roudbaraki, M., Lehen'kyi, V., Bordat, P., Prevarskaya, N., & Skryma, R. (2006, septembre). TRPC7 is a receptor-operated DAG- activated channel in human keratinocytes. Journal of investigative dermatology, 126(9), 1982-1993. doi:10.1038/sj.jid.5700352


Vanden Abeele, F., Bidaux, G., Gordienko, D., Beck, B., Panchin, Y., Baranova, A. V., Ivanov, D., Skryma, R., & Prevarskaya, N. (2006, août). Functional implications of calcium permeability of the channel formed by pannexin 1. The Journal of cell biology, 174(4), 535-546. doi:10.1083/jcb.200601115


Flourakis, M., Van Coppenolle, E., Lehen'kyi, V., Beck, B., Skryma, R., & Prevarskaya, N. (2006, juin). Passive calcium leak via translocon is a first step for iPLA2-pathway regulated store operated channels activation. The FASEB journal, 20(8), 1215-1217. doi:10.1096/fj.05-5254fje


Thebault, S., Flourakis, M., Vanoverberghe, K., Vandermoere, F., Roudbaraki, M., Lehen'kyi, V., Slomianny, C., Beck, B., Mariot, P., Bonnal, J.-L., Mauroy, B., Shuba, Y., Capiod, T., Skryma, R., & Prevarskaya, N. (2006, février). Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells. Cancer research, 66(4), 2038-2047. doi:10.1158/0008-5472.CAN-05-0376


Zholos, A., Beck, B., Sydorenko, V., Lemonnier, L., Bordat, P., Prevarskaya, N., & Skryma, R. (2005, février). Ca(2+)- and volume-sensitive chloride currents are differentially regulated by agonists and store-operated Ca2+ entry. The Journal of general physiology, 125(2), 197-211. doi:10.1085/jgp.200409161

Beck et al., 2015

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Vercauteren Drubbel et al.,

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